On the other hand, enforced expression of TAF4 promoted expression of pluripotency- associated KLF4, OCT4 and NANOG, and NC-related MSX2, PAX7, SOX10 and SNAI1 (Fig. 5b), reaffirming the critical role of hTAF4-TAFH activity in the maintaining of multipotency in melanoma cells. This evidence concerns the gene NANOG and melanoma.