Consistent with these findings, both, iMels and cancer cells, showed high expression of CDH2 and matrix metallopeptidase 3 (MMP3) mRNAs and low expression of CDH1 and keratin 14 (KRT14) mRNAs at 72 h after TAFH RNAi (Fig. 4b). The gene discussed is CDH2; the disease is cancer.