In differentiation-supported conditions, TAFH RNAi-treated melanoma cells started to express chondrogenic-specific SOX9, NKX3.2 and RUNX2; adipogenic PPARG; and neurogenic NTRK2, NF-M and SYP mRNAs at 48 h post-stimulation of differentiation (Fig. 3b). The gene discussed is RUNX2; the disease is melanoma.