Given that aberrant activation of notch signaling is a common feature of EMT and contributes to non-small cell lung cancer through maintenance of the cancer stem cell compartment it is conceivable that TGF-β1-induced HDAC6-dependent deacetylation of HSP90 contributes to key signaling networks implicated in EMT20. The gene discussed is TGFB1; the disease is non-small cell lung carcinoma.