Likewise, we found two genes whose monitored up-regulation, as a consequence of PRSE treatment, can be consistent with an anti-invasion effect: i) Htatip2 (named also Tip30), a putative metastasis suppressor gene which is inversely correlated with lymph node metastasis in breast cancer patients, and ii) Gpnmb (also named Osteoactivin/HGFIN), a gene with a controversial role in the metastatic process46, 47. Here, GPNMB is linked to breast cancer.