There is also a rearrangement that fuses the first 20 exons of the transcriptional co-activator CREBBP to the antisense strand of CLUAP1. CREBBP is a well-known cancer gene that can be targeted by inactivating point mutations (Pasqualucci et al., 2011) or, in leukemias, involved in canonical fusion genes (Camós et al., 2006). This evidence concerns the gene CREBBP and cancer.