CREBBP and leukemia: There is also a rearrangement that fuses the first 20 exons of the transcriptional co-activator CREBBP to the antisense strand of CLUAP1. CREBBP is a well-known cancer gene that can be targeted by inactivating point mutations (Pasqualucci et al., 2011) or, in leukemias, involved in canonical fusion genes (Camós et al., 2006).