Among the 12 leiomyoma-specific marker genes, the combination of the 10 marker genes (ALX1, CBLN1, CORIN, FOXP1, GATA2, IGLON5, NPTX2, NTRK2, PRL and STEAP4) completely differentiated between the leiomyoma and normal myometrium in the hierarchical clustering based on the DNA methylation profiles (Fig. 2). The gene discussed is CBLN1; the disease is leiomyoma.