At the molecular level, using genetic Ifngr1−/− and Il7r−/− mice and different adoptive transfer systems with WT, Ifngr1−/− and Il7r−/− total T cells, we illustrate that the interdependence between IL-7 and IFN-γ signalling in T cells underpins the anti-tumour immune responses elicited by the combination therapy. The gene discussed is IFNG; the disease is neoplasm.