Additional analysis of tumour-infiltrating Ifngr1−/− T cells revealed a significantly higher proportion of Treg in CD4+ T cells, reduced ratios of CD4+ non-Treg/Treg and CD8+/Treg cells, and decreased CD4+IFN-γ+ TILs, as compared to tumour-infiltrating WT T cells (Supplementary Fig. 6E–G). The gene discussed is CD8A; the disease is neoplasm.