IL18 and acute kidney injury: Kashani et al performed a multicentre study in critically ill adults and found that urinary insulin-like growth factor binding protein 7 (IGFBP-7) and tissue inhibitor of metalloproteinase (TIMP)-2 (both are inducers of G1 cell cycle arrest) were the best performing biomarkers for AKI from an extensive list of 340 candidate biomarkers (including KIM-1, NGAL, IL-18, Cys-C and L-FABP).