The use of TIMP-2 and IGFBP-7 in the paediatric population has not been extensively investigated, but one small study involving a heterogeneous population of children and neonates found NephroCheck had a moderate performance in predicting the need for RRT (AUC 0.67).23 Further paediatric data are required to assess these and other combinations of AKI biomarkers. The gene discussed is IGFBP7; the disease is acute kidney injury.