REST and Parkinson disease: Here UCHL1 (Ubiquitin Carboxyl-Terminal Esterase L1), a susceptibility gene for PD and a potential target for disease-modifying therapies [73], was significantly down-regulated by HSV-1 infection, and a novel, HSV-1 induced lncRNA (located at 4:68282460–68285959), negatively correlated with REST and UCHL1, thus could potentially inhibit the expression of REST and UCHL1.