For example, two PCGs, HIST1H2AB and HIST1H2AC, which were both significantly down-regulated about 2.5 fold after HSV-1 infection, were negatively associated with one annotated lncRNA, ZNRD1-AS1 (significantly up-regulated about 4 fold by the infection) (Fig. 3d). The gene discussed is POLR1H; the disease is infection.