CD4 and bacterial infectious disease with sepsis: The activated CD4+ T lymphocyte subsets showed a somewhat different pattern than the other lymphocyte subsets in group A. The activated CD4+ T lymphocyte counts increased early during the course of infection into the onset of PCR-positivity and peak bacteremia, and then, they markedly decreased and reached a nadir at day 42 pi (pF < 0.0001); this pattern was also present but less pronounced in group B (pF = 0.0249, Figure 6F).