We have previously demonstrated, in a mouse model of LPS-induced acute lung inflammation, that neutrophils can alter their expression of chemokine receptors when migrating into inflamed lung.12 Therefore, in order to determine whether the cell surface chemokine receptor expression on neutrophils changes during neutrophil transmigration in ARDS, we examined whether the surface expression of CXCR1, CXCR2 (receptors for CXCL8), and CCR1, CCR2 and CCR3 (receptors for CCL2 and CCL7) differed on neutrophils isolated from the blood and BAL fluid of patients with ARDS. The gene discussed is CCR1; the disease is acute respiratory distress syndrome.