CXCL8 and acute respiratory distress syndrome: The chemokine CXCL8 is considered to be the archetypal neutrophil chemoattractant and levels of CXCL8 have been directly associated with the number of neutrophils recruited into the inflamed lung during ARDS, as well as with disease severity and poor clinical outcome.21–23 Although CCL2 has previously been shown to be elevated in BAL fluid of patients with ARDS,11 its specific role in mediating neutrophil migration in this disease setting has not been comprehensively explored.