CCL2 and pneumococcal infection: We have previously demonstrated that CCL2 and CCL7 are elevated in a mouse model of LPS-induced acute lung inflammation12 and a mouse model of S. pneumoniae infection.13 Furthermore, neutralisation of either CCL2 or CCL7 reduced the number of neutrophils isolated from the BAL fluid of LPS-treated mice, while neutralisation of CCL7 reduced the neutrophil numbers following pneumococcal infection.