Indeed, the levels of CXCL8 have been positively correlated with the number of neutrophils recovered from patients with ARDS8 and with disease severity.9, 10 However, several studies have reported that other chemokines may be elevated in ARDS.11 Furthermore, we have recently reported that neutrophil recruitment in the lung airspaces, in response to lipopolysaccharide(LPS)-induced lung inflammation, is mediated by the chemokine (C-C motif) ligand (CCL)2 and CCL7,12 while CCL7 regulates neutrophil recruitment in response to acute infection with the bacterium Streptococcus pneumoniae. This evidence concerns the gene CXCL8 and acute respiratory distress syndrome.