EPHX1 and type 2 diabetes mellitus: In our present study, non-obese T2DM also influenced expression of genes related to epoxide metabolism (down-regulation of Epoxide hydrolase 2, cytoplasmic, (Ephx2); glutathione S-transferase alpha 2, (Gsta2) and up-regulation of Epoxide hydrolase 1, microsomal, (xenobiotic) (Ephx1) (Fig. 3).