In addition, elevated expression of the pro-apoptotic protein BCL2-interacting mediator of cell death (BIM)/BCL2L11, a marker of onset of anoikis in breast cancer cells, was detected in suspension cultures of LM-SMARCE1-KD cells, but not in LM-EV cells (Fig. 5a). The gene discussed is BCL2L11; the disease is breast cancer.