Furthermore, low APOA-I levels were found to be associated with a higher risk of several cancers such as breast cancer, and gastic cancer.[25,26] As a result, we infer that there are distinct etiological relationships between lipid profiles and pancreatic adenocarcinoma, in which APOA-I play an important part and it may become a potential biomarker for PDAC. The gene discussed is APOA1; the disease is pancreatic adenocarcinoma.