MMP9 and insomnia: Chai-Hu-Jia-Long-Gu-Mu-Li-Tang was used to relieve symptoms of hypogonadism, including insomnia, hot flushes, and erectile dysfunction, but did not lead to changes in serum testosterone levels.[19] Furthermore, Ha et al[20] demonstrated that extracts from Chai-Hu-Jia-Long-Gu-Mu-Li-Tang had inhibitory effects on tumor-specific matrix metalloproteinases (MMP)-2 and MMP-9 activities, which are associated with tumor recurrence and progression in prostate cancer.[21] According to the literature, the major components of Chai-Hu-Jia-Long-Gu-Mu-Li-Tang also have anticancer effects.