As previously suggested, this gap could suggest isolated CNS infection without significant spillover into venous blood or that BDG may be more rapidly cleared in blood than in CSF.[26] According with the results of the fungal meningitis rabbit model proposed by Petraitiene et al,[29] plasmatic levels of β-glucan lower than CSF levels hint a compartmentalization of this polymeric carbohydrate, with higher concentrations within the CNS not readily crossing the blood–brain barrier. This evidence concerns the gene PPIB and fungal meningitis.