CBX4 and hepatocellular carcinoma: For example, Cbx4/Pc2 regulates TUG1 and MALAT1/NEAT2.[10] On one hand, Cbx4 has been reported as a diagnostic marker for HCC and promote HCC angiogenesis.[11,12] On the other hand, TUG1 and MALAT1/NEAT2 are upregulated in HCC.[13,14] Therefore, lncRNAs may be potential diagnostic markers and therapeutic targets for HCC in clinical practice.