In patients with ALT ≥ 2 × ULN and HBV DNA > 2000 IU/mL (n = 403), crude HCC incidence was 1209.15 cases per 100,000 person-years in untreated patients versus 473.55 cases per 100,000 person-years in treated patients. This evidence concerns the gene GPT and hepatocellular carcinoma.