GPT and hepatocellular carcinoma: The progression of CHB is a multistage, multifactorial process involving interactions among host, environmental, and viral factors.[5] Pivotal studies on CHB have identified many important virological and host predictors of HCC: hepatitis B e antigen (HBeAg) serostatus, alanine aminotransferase (ALT) levels, and HBV DNA levels.[6–8] ALT is a sensitive indicator of hepatocellular injury and, in conjunction with HBV DNA levels, has routinely been used in clinical practice to identify patients who would benefit for anti-CHB treatment.[9,10]