DM is a systemic chronic inflammation disease associated with increased risk of primary liver cancer.[29] Biondi et al[30] investigated that the molecular marker, chromogranin A, maybe a useful marker for early diagnosis of HCC.[31] This study shows that patients with BTI may have increased risk of liver cancer (aHR: 1.53; 95% CI: 1.07–2.18). This evidence concerns the gene CHGA and liver cancer.