IGHE and cancer: IL-4 is a key cytokine associated with allergy.[18] It confers immunoregulatory activity by interacting with its cognate receptors, a complex of IL-4Rα with either the common γ-chain or the IL-13R chain α1.[18,19]IL4R encodes the alpha chain of the interleukin-4 receptor that can bind interleukin 4 and interleukin 13 to regulate IgE production.[20] Hosoyama et al[21] showed that IL-4R signaling pathway could modulate the progression of tumor cells, and it could be a promising therapeutic target for cancer by inhibiting this signaling pathway.