IGHE and allergic disease: Furthermore, certain IL4R SNPs, such as rs1805010, has already been shown to have a functional effect on the IgE level by upregulating the receptor's response to IL-4, which in turn results in activation of the Stat6 pathway.[22] So, mutations in genes of IL-4, IL-13, and their receptors may break up the balance of cytokines network and contribute to allergy and carcinogenesis.