IL4R and central nervous system cancer: Variants in inflammatory genes contribute to individual susceptibility in risk for atopic disorders, which have been linked to protection against various malignancies, including gliomas.[14,15] Previous studies reported that rs1801275 in the IL4R gene could increase the risk of glioblastoma in a population-based case-control study.[16,17] The IL4R gene affects both the risk of glioma and survival time.