IL4R and malignant glioma: To date, recent reports suggest that some gene polymorphisms can influence glioma survival, including HLA-A, HLA-B, GLTSCR1, ERCC2, GSTP1, and GSTM1. [5–8] Scheurer ME et al. reported that the IL4R rs1805016 was significantly protective against mortality over time of glioma patients, and IL4R rs1805016 and rs1805015 TT genotypes were both significantly associated with survival beyond 1 year among high-grade glioma patients.[9] These studies remind that genetic factors may be important in glioma prognosis.