Of note, overexpression of CCND1 and CCND2 is one of the most common hallmarks of various cancer types, due to its relatively high amplification frequency (15%–40%) and the upregulation of its mRNA and protein expression in a variety of tumors including NSCLC, breast cancer, melanoma, and pancreatic cancer [32]. This evidence concerns the gene CCND1 and non-small cell lung carcinoma.