We used Solexa sequencing to determine the miRNA expression profile in lung tissues of NSCLC models (L822T1/Kras+/+, L903T1/Kras+/++LKB1−/− and L703T2/Kras+/++p53−/−) and normal mouse (L1805), and found that miR-146a-5p was significantly downregulated in NSCLC, compared to the normal control (Supplementary Figure S1). This evidence concerns the gene TP53 and non-small cell lung carcinoma.