To further study the function of miR-146a-5p in NSCLC, bioinformatics analysis was used to predict potential targets, the results from which revealed hundreds of mRNAs matching the miR-146a-5p seed sequence, including cell cycle factors CCND1 and CCND2, which are downstream molecules regulated by MAPK pathway. The gene discussed is CCND2; the disease is non-small cell lung carcinoma.