Although the regulating mechanism still remains unclear, it was reported that down-regulation of Cbl-b led to stronger activation of p38 mitogen activated protein kinase (p38 MAPK) in breast cancer cells [27]; p38 MAPK inhibitor could suppressed the up-regulation the expression of TGF-β1 induced by angiotensin II in cultured adult atrial fibroblasts [28]. The gene discussed is TGFB1; the disease is breast cancer.