CD8A and neoplasm: Prior to RCT especially high numbers of FoxP3+ cells (698 ± 578 cells mm−2) were observed in the stromal compartment and after surgery FoxP3+ cell counts had clearly declined (central tumour 222 ± 306 cells mm−2, invasive front 103 ± 131 cells mm−2) to levels similar to or lower than CD8+ cell counts (Figure 1E, 1H).