These miRNAs, now known as regulators of cell cycle which also target CCND1, CCND2, CD25A, MCL-1 and WNT3 [63, 64], have been found downregulated in MM [65, 66] and shown to be involved in BMSCs-mediated drug resistance through induction of IL-6 and cell cycle progression [67, 68]. This evidence concerns the gene IL6 and Miyoshi myopathy.