While c-MYC-repressed miRNAs (miR-15a/16-1, miR-26a, miR-29, miR-34a, and miR-150) and their role in regulation of c-MYC-mediated responses (survival, inhibition of apoptosis) have been well characterized in c-MYC-driven lymphomas [57], how/whether miRNAs can regulate c-MYC-mediated functional responses such as drug resistance in MM is still not clear. Here, MYC is linked to Miyoshi myopathy.