To further confirm the role of miR-450b-5p in the progression of CRC, SIAH1 and SFRP2 ORF constructs without 3′UTRs were transfected in SW480 cells with miR-450b-5p overexpressing (Figure 6A), and their effects on growth and apoptotic rate were detected. This evidence concerns the gene SFRP2 and colorectal carcinoma.