Taken altogether, the above results revealed that AP-1, a downstream gene of KRAS signaling, up-regulates the expression of miR-450b-5p, which activates Wnt signaling and inhibits apoptosis by decreasing the expression of SIAH1 and SFRP2, resulting in CRC progression (Figure 6G). Here, SIAH1 is linked to colorectal carcinoma.