Binding of HMGB1 to TLR4, following the calreticulin exposure on the surface of tumor cells and ATP secretion, is associated with the recruitment and maturation of dendritic cells (DCs) and the consequent proliferation of tumor-reactive CD8+ T lymphocytes, which are presented tumor-associated antigen by mature DCs [10]. The gene discussed is HMGB1; the disease is neoplasm.