NPM1 and acute myeloid leukemia: The classification of AML into prognostic subgroups depending on the specific gene mutations, the so-called “AML with gene mutations”, includes mutations in Fms-like tyrosine kinase 3 (FLT3), nucleophosmin 1 (NPM1) and chloramphenicol acetyltransferase-box enhancer-binding protein alpha (CEBPA) [40].