Recently, we have shown that the POZ/domain and kruppel zinc finger (POK) transcription factor PATZ1 plays a crucial role in the negative autoregulation of BCL6 expression, and that Patz1-knockout mice develop a thymus neoplastic phenotype caused by BCL6 overexpression, suggesting that PATZ1 could be involved in BCL6 expressing human B cell lymphomas [13]. This evidence concerns the gene BCL6 and B-cell non-Hodgkin lymphoma.