PMAIP1 and Miyoshi myopathy: We also observed induction of Mcl-1 binding partners Bim, Noxa and Puma [42] after OBX treatment and the combination, further suggesting Mcl-1 inhibition It has been shown in a prior study that OBX was able to inhibit Mcl-1/Bak interaction but not Bcl-2/Bak interaction in MM cells (Trudel et al) further suggesting that OBX induced pro-apoptotic Bim, Noxa and Puma up regulation is mediated through Mcl-1 inhibition.