Suppression of tumor vasculature was assessed through the detection of MVD as shown in Figures 8 and 9, the suppressive effect of DTIC-NPs-DR5 mAb (Group A) on tumor angiogenesis was more significant than other groups except the DTIC+ mAb (Group B) (p<0.05). The gene discussed is TNFRSF10B; the disease is neoplasm.