Since altering GSK3β activity affects the trimethylation of H3K27 and the expression of EZH2-targeted genes, and GSK3β-EZH2 interaction has been shown in nasopharyngeal cancer cells [26], we asked whether this interaction occurs in our system, including breast cancer and mammalian epithelial cells. This evidence concerns the gene EZH2 and nasopharyngeal carcinoma.