CD8A and T-cell large granular lymphocyte leukemia: The diagnosis of T-LGL leukemia is based on peripheral blood expansion of the leukemic LGL population (>0.5 × 109/l) in association with CD3+/CD8+ phenotype and evidence of clonality as suggested by clonal rearrangement of the T-cell receptor gene using PCR or flow cytometry.1, 2, 3