BRAF and metastatic malignant neoplasm in the lymph nodes: The aggressive pathologic characteristics, lymph node metastasis (LNM) and extrathyroidal extension (ETE) were correlated with the 3 molecular subtypes (Fig 2C); higher frequency of LNM (37.04%) or ETE (61.73%) was found in the BRAF–like group, while less or no LNM or ETE was observed in the RAS–like group (15.09% of LNM, 11.32% of ETE) or NBNR group (0.00% of LNM, 8.70% of ETE) (For both categories; p < 0.0001).