In colorectal cancer cells, but not HeLa cells with their intact Wnt-β-catenin pathway, Tankyrase and AXIN1/2 have been shown to colocalize in β-catenin degradasomes induced by Tankyrase inhibitors (de la Roche et al., 2014, Martino-Echarri et al., 2016, Thorvaldsen et al., 2015). The gene discussed is TNKS; the disease is colorectal cancer.