Heterotopic ossification (HO), the pathologic formation of ectopic bone in soft tissues, occurs after extremity trauma, burn injury, spinal cord, traumatic brain injuries and orthopaedic procedures.[1–7] Additionally, a point mutation in ACVR1 causes fibrodysplasia ossificans progressiva (FOP), a debilitating condition in which heterotopic bone forms independent of trauma.[8] Due to the variety of settings in which HO occurs, several models have been developed to examine in vivo treatment strategies including mouse and rat trauma models, and transgenic mouse models[9–15]. This evidence concerns the gene ACVR1 and fibrodysplasia ossificans progressiva.