Given the role of Rae1 to promote cell proliferation and increase organ size, its conserved regulation by the Hippo pathway in both cultured insect and mammalian cells, and the synthetic tissue lethality phenomenon observed in Hippo-compromised tissue, we propose that Rae1 may represent a novel therapeutic target in cancers arising due to loss of Hippo Pathway tumor suppression (Fig 10). This evidence concerns the gene RAE1 and cancer.