Similarly, in samples from patients suffering from depression, there were no differences in the expression of any FosB isoform in the PFC, while the HPC showed decreases in full-length FosB (F(2,35) = 1.98, p = 0.048) and ΔFosB (F(2,30) = 1.38, p = 0.027), as well as in the 23 kDa band (F(2,21) = 2.05, p = 0.022) and the 20 kDa band (F(2,18) = 0.97, p = 0.028) (Fig 4C and 4D). This evidence concerns the gene FOSB and major depressive disorder.