CASP3 and autoimmune thrombocytopenic purpura: Concerning human ITP, evidence of platelet apoptosis, including caspase 3, 8 and 9 activation, was shown in children with acute ITP, which was ameliorated by intravenous immunoglobulin infusion [14], whereas another study revealed that platelets from adult chronic ITP patients displayed increased phosphatidylserine exposure associated with dendritic cell dysfunction, although other markers of platelet apoptosis could not be demonstrated in this cohort [15].