A large number of studies established the crucial role of auto-antibodies in ITP pathogenesis, demonstrating that main platelet antigenic targets are the fibrinogen receptor glycoprotein complex (GP) IIb-IIIa and the von Willebrand receptor GPIb-IX [4, 5] while a lower proportion of auto-antibodies react with the collagen receptors GPIa-IIa and GPIV [6]. Here, ITGA2B is linked to autoimmune thrombocytopenic purpura.