Whole exome sequence analysis of 23 tumor normal pairs uncovered a median of 4 coding mutations per tumor (not including those identified in TSC1/TSC2, range 0–12), with 3 of 78 (4%) frame-shift deletions, 3 of 78 (4%) in-frame deletions, 2 of 78 (3%) nonsense, 2 of 78 (3%) splice site, and 68 of 78 (87%) missense mutations (Table 2). The gene discussed is TSC1; the disease is neoplasm.