POLE and cancer: Our findings of the low somatic mutation rate of angiomyolipoma contrast sharply with cumulative cancer genome sequencing studies that have shown that adult malignancies have a wide range of non-synonymous mutations per cancer, ranging from 8 (chronic lymphocytic leukemia) to over 1,000 (colorectal cancer with microsatellite instability; other cancers with POLE mutations) [35, 41].