AKT1 and neoplasm: We have earlier reported decreased activity of LDH-A by QUE which is correlated with markedly delayed tumor formation in DL mice [11]. AKT stimulates glycolysis by increasing the expression and membrane translocation of glucose transporters and by phosphorylating key glycolytic enzymes such as hexokinase and phosphofructokinase2 as well as phosphorylating mTOR [40].