Single nucleotide polymorphisms (SNPs) in hepatocyte growth factor RAB 3 GTPase activating protein 1 (RAB3GAP1), interleukin 1β (IL1B), cadherin 11 (CDH11), negative regulator of ubiquitin like protein 1 (NUB1), collagen type XXVII A1 (COL27A1) and lysyl oxidase (LOX) were identified by genome wide association studies (GWAS) as risk factors for keratoconus [53]. This evidence concerns the gene NUB1 and keratoconus.