DNM2 and muscular dystrophy: If SCNN1A is mechanosensitive in human skeletal muscle, then like mechanosensitive calcium channels, it may contribute to ionic imbalance in response to stretch and in individuals with muscular dystrophy.49 Given that cytoskeletal proteins are common targets of caspases, there is a reason to suspect that any ionic imbalance resulting from SCNN1A hyperactivation would lead to cytoskeletal remodelling and/or dystrophy; therefore, the role of SCNN1A in human skeletal muscle would seem to warrant further investigation.