TNFRSF9 and chronic kidney disease: Inflammation in WAT is characterized by recruitment of macrophages, including activated M1 and M2 macrophages.55 Activated macrophages in the WAT are an important source of adrenaline and noradrenaline and have been associated with an increase in uncoupled respiration and energy expenditure in mice.56 We showed that the phenomenon of adipose tissue browning was more advanced in 12‐month‐old Ctns−/− vs. CKD controls, as indicated by the higher expression of browning markers CD137 and Tbx1 (Figure7A).