CTNS and chronic kidney disease: Epididymal WAT exhibited higher expression of Ppargc1α, Pgc1α, and glucose transporter Glut1 in Ctns−/− mice than in WT controls, but no difference was found in expression of genes involved in lipolytic metabolism (Acox1, Acstl1, Atg1, and Hsl) in Ctns−/− mice relative to WT or CKD mice (Figure6C).