NF1 and neurocutaneous syndrome: Over the years there has been much debate and some authors have suggested the inclusion of other ophthalmic diseases with neurocutaneous manifestations in the group of phakomatoses [2–6], but advances in molecular genetics provide evidence of the role of tumor suppressor genes in the pathophysiogenetic mechanisms of NF1, TSC, and VHL disease, which all have a familial pattern of inheritance, variable expressivity, and multisystem tumors with a risk of malignant transformation and can be considered the “true phakomatoses” [7–9].