Kannan and Quine [27] found that ellagic acid administered to rats in a model of hypertrophy and arrhythmias induced experimentally reduced hyperlipidemia and lipid peroxidation in these animals because of its ability to inhibit the activity of 3-hydroxy-3-methylglutaryl-CoA reductase. The gene discussed is HMGCR; the disease is hyperlipidemia.