We showed that 2-DG and/or melatonin affected SOD, catalase, Bcl-2, and Bax proteins in rat insulinoma INS-1E cells (Figure 4), suggesting that 2-DG or 2-DG plus melatonin influences antioxidant and prooxidant proteins through a mechanism involving mitochondrial ROS. This evidence concerns the gene CAT and pancreatic insulinoma.