For instance, long-term treatment with hormones that are members of the growth hormone family, such as vascular endothelial growth factor (VEGF) can cause GSK3/Akt/PI3K insensitivity and activate GSK3 in cultured cells [5], whereas repeatedly administrating growth hormone, approximately equating to long-term hormone treatment is often associated with adverse effects such as diabetes and glucose intolerance in humans [19], which is attributable to possible high GSK3 activity. This evidence concerns the gene AKT1 and diabetes mellitus.