Although data obtained from gene-knockout studies were confounded by the presence of a truncated PLIN2 segment in the mouse model [34], it is apparent that PLIN2 depletion in mice, even though the ablation may not be complete, is associated with amelioration of diet-induced hepatosteatosis, obesity, and adipocyte inflammation [32]. The gene discussed is PLIN2; the disease is obesity due to melanocortin 4 receptor deficiency.