If the in vitro cell culture data can be extrapolated to in vivo situation such as hyperlipidemia/obesity (since GSK3 and PLIN2 are ubiquitously expressed), both acute and chronic lipid effects may generate over-suppressed and uncontrolled GSK3 activity, potentially causing divergent damages [5, 6, 10]. This evidence concerns the gene PLIN2 and obesity due to melanocortin 4 receptor deficiency.