The inflammation parameters in clinical chemistry, occasionally with biomarker status, are acute phase proteins, that is, CRP, serum amyloid A, fibrinogen, tryptase [44], haptoglobin, procalcitonin [45], interleukin-6, and again CRP used to classify disease stage of rheumatoid arthritis [20] and now even to estimate extent of fitness and senescence [11]. The gene discussed is CRP; the disease is rheumatoid arthritis.