DNASE1 and psoriasis: As shown in Fig. 6b, control neutrophils stimulated to undergo NETosis with PMA induced HBD-2 protein secretion by keratinocytes, which was partially attenuated by pre-treatment of NETs with DNase I. Similarly, netting neutrophils from psoriasis patients induced HBD-2 protein secretion by keratinocytes, which was partially suppressed by DNase I pre-treatment.