Mincle (Clec4e) is a myeloid receptor that has been reported to recognize necrotic cells via detection of the nuclear protein Sap130.17 Mincle regulates inflammatory responses to fungal and mycobacterial pathogens18, , –21 via spleen tyrosine kinase (Syk), and the caspase recruitment domain protein Card9.22,23 Inhibition of Syk limits thrombosis and vascular inflammation in a variety of animal models of sterile injury;24 therefore, the Mincle/Syk axis is likely to also contribute to the pathophysiology of ischemic stroke. This evidence concerns the gene CLEC4E and ischemic stroke.