CLEC4E and ischemia: Microglia are radiation-resistant and thus retained in the recipient animal in bone marrow chimeras,39 and we had expected that these cells would be the most likely source of Mincle-directed inflammation; however, microglia isolated from sham-operated or tMCAO brains one day after the injury did not express the Clec4e mRNA, and the transcriptional profile of Mincle-deficient microglia did not deviate from that of isogenic controls, after sham surgery or ischemia.