To test whether the expansion of SOX2-expressing cells occurred prior to HGSOC development, we analyzed the fallopian tubes of 48 women at high risk of developing ovarian cancer because they were BRCA1 or BRCA2 gene mutation carriers and therefore underwent prophylactic salpingo-oophorectomy (Fig. 3c, Table 2). The gene discussed is BRCA2; the disease is ovarian carcinoma.